Oxygen therapy for skin. is a relatively new area of research, and a recent study has shown that hyperbaric oxygen therapy (HBOT) can have significant benefits for skin aging.
The study involved healthy volunteers with mild to moderate skin aging, and the results suggest that HBOT may be an effective treatment for improving skin aging.
What Is Skin Aging?
Skin aging is a complex biological process that is influenced by both intrinsic and extrinsic factors. Intrinsic aging is the natural aging process that occurs due to genetic factors, while extrinsic aging is caused by environmental factors such as UV radiation, pollution, and smoking.
Both intrinsic and extrinsic aging lead to a decline in the structural and functional integrity of the skin, resulting in wrinkles, sagging skin, and uneven pigmentation.
Hyperbaric oxygen therapy (HBOT) is a medical treatment that involves breathing pure oxygen in a pressurized chamber. The high pressure and concentration of oxygen promote the delivery of oxygen to the tissues, which can have a range of therapeutic effects, including improved wound healing and tissue regeneration.
A prospective clinical trial was conducted to investigate the effect of HBOT on the pathophysiology of skin aging. The trial involved 30 healthy volunteers with mild to moderate skin aging.
Participants received HBOT sessions for 5 days a week for a total of 4 weeks. Skin biopsies were taken before and after the treatment to evaluate changes in skin physiology.
The results of the study showed that HBOT had a significant effect on the pathophysiology of skin aging. There was an increase in collagen synthesis, which led to improved skin elasticity and firmness.
The treatment also led to a decrease in skin thickness and a reduction in the number of fine lines and wrinkles. The study also found that HBOT had a positive effect on skin hydration and pigmentation.
Overall, the study suggests that HBOT may be an effective treatment for improving skin aging. However, further research is needed to determine the optimal treatment protocol that is required, as well as the long-term effects of the treatment on skin physiology.involved
Oxygen Therapy For Skin Study Details
The study enrolled adults aged 64 and older who were living independently and in good cognitive and functional status without pathological cognitive decline.
They did not have any history of cardiac or cerebrovascular ischemia for the last year prior to inclusion. The study was performed between 2016-2020 at the Shamir (Assaf-Harofeh) Medical Center in Israel.
Exclusion criteria included previous treatment with HBOT for any reason during the last three months, any history of malignancy during the last year, any pathological cognitive decline, severe chronic renal failure, uncontrolled diabetes mellitus, taking immunosuppressants, MRI contraindications, active smoking, or pulmonary diseases.
The study was designed as a prospective clinical trial, and the participants were assigned to a three-month control period followed by three months of HBOT daily sessions.
The study cohort was part of a larger cohort of normal ageing population studied at the Center.
Skin biopsies were optional due to the invasiveness of the biopsy. The study demonstrates that HBOT had significant aging modulation effects by decreasing senescent cells, inducing angiogenesis, and increasing elastic fiber length and stability, and collagen density.
The study focused on intrinsic aging by obtaining skin biopsies from a light-protected area, which allowed the researchers to gain a better understanding of HBOT’s effects at the tissue level.
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